Yes, Ganciclovir G2536 can be dissolved in DMSO for in vitro application. Additionally, Ganciclovir is available in SML2346 as a ready-made DMSO solution, which is directly applicable for in vitro application.
G2536
Ganciclovir
≥99% (HPLC), powder, viral DNA elongation inhibitor
Sinónimos:
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
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100 MG
549,00 €
549,00 €
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100 MG
549,00 €
About This Item
Fórmula empírica (notación de Hill):
C9H13N5O4
Número de CAS:
Peso molecular:
255.23
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
549,00 €
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Nombre del producto
Ganciclovir, ≥99% (HPLC), powder
Nivel de calidad
Ensayo
≥99% (HPLC)
Formulario
powder
color
white
solubilidad
0.1 M HCl: 10 mg/mL
ε (coeficiente de extinción)
12.0 at 256 nm at 1 mM
espectro de actividad antibiótica
viruses
Modo de acción
DNA synthesis | interferes
emisor
Roche
temp. de almacenamiento
2-8°C
cadena SMILES
NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1
InChI
1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
Clave InChI
IRSCQMHQWWYFCW-UHFFFAOYSA-N
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Descripción general
Chemical structure: nucleoside
Aplicación
Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.
Acciones bioquímicas o fisiológicas
Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.[1] The cell cycle is irreversibly arrested at the G2-M checkpoint.[2] Gap junction involvement in the ganciclovir bystander effect has been studied.[3] Ganciclovir has been used to study loss of telomeres[4] and to evaluate sensitivity of viruses to antiviral treatments.[5]
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.[1] The cell cycle is irreversibly arrested at the G2-M checkpoint.[2] Gap junction involvement in the ganciclovir bystander effect has been studied.[3] Ganciclovir has been used to study loss of telomeres[4] and to evaluate sensitivity of viruses to antiviral treatments.[5]
Características y beneficios
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Nota de preparación
Ganciclovir is soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml).
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.
Ganciclovir is tested for solubility in 0.1M HCl at 10 mg/mL. The compound is also soluble in DMSO at 5 mg/mL.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Muta. 1B - Repr. 2
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Artículos
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Discover Bioactive Small Molecules for ADME/Tox
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Can Ganciclovir G2536 be dissolved in DMSO for in vitro testing?
1 respuesta-
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can ganciclovir be dissolved in PBS or saline? can ganciclovir be neutralized by 0.1M NaOH after dissolving in 0.1M HCl
1 respuesta-
Product G2536, Ganciclovir is tested for solubility in 0.1M HCl at 10 mg/mL. The compound is also soluble in DMSO at 5 mg/mL. While pH adjustment for neutralization has not been tested, this is a typical practice in pharmaceutical-grade solutions for injection. It is anticipated that no issues would arise regarding stability or precipitation.
See below for a link to a typical product insert, page 14 under Description:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209347lbl.pdf¿Le ha resultado útil?
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Can ganciclovir be resuspended in solutions other than HCl? If so, what is the solubility and storage condition? Thank you.
1 respuesta-
References state that this chemical is soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml).
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.
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