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Merck
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G1626

Sigma-Aldrich

L-Glutamic acid monosodium salt hydrate

≥99% (HPLC), powder

Sinónimos:

(S)-2-Aminopentanedioic acid, L-Glutamic acid monosodium salt, Glu, MSG, Monosodium glutamate

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About This Item

Fórmula empírica (notación de Hill):
C5H8NNaO4 · xH2O
Número de CAS:
142-47-2
Peso molecular:
169.11 (anhydrous basis)
Número MDL:
MFCD00013074
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24895069
NACRES:
NA.32

Análisis

≥99% (HPLC)

formulario

powder

color

white to off-white

InChI

1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2;

Clave InChI

JYDGDQPVBSBYRT-UHFFFAOYSA-N

Información sobre el gen

human ... GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , GRINA(2907)
mouse ... GRIK1(14805) , GRIK2(14806) , GRIK3(14807) , GRIK4(110637) , GRIN1(14810) , GRIN2A(14811) , GRIN2B(14812) , GRIN2C(14813) , GRIN2D(14814) , GRIN3A(242443) , GRIN3B(170483) , GRINA(66168)
rat ... GRIK1(29559) , GRIK2(54257) , GRIK3(298521) , GRIK4(24406) , GRIN1(24408) , GRIN2A(24409) , GRIN2B(24410) , GRIN2C(24411) , GRIN2D(24412) , GRIN3A(191573) , GRIN3B(170796) , GRINA(266668)

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Descripción general

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

Aplicación

L-Glutamic acid monosodium salt hydrate has been used-
  • as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine
  • as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice
  • as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce′s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants
  • as a component of the stock solution for the equilibration of intracellular and extracellular [H+] in segmental nerves obtained from the ventral ganglion of Drosophila larvae
  • as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage

Acciones bioquímicas o fisiológicas

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Adam J Rossano et al.
The Journal of physiology, 591(7), 1691-1706 (2013-02-13)
All biochemical processes, including those underlying synaptic function and plasticity, are pH sensitive. Cytosolic pH (pH(cyto)) shifts are known to accompany nerve activity in situ, but technological limitations have prevented characterization of such shifts in vivo. Genetically encoded pH-indicators (GEpHIs)
Serum-free media for neural cell cultures.
Price, P J, and Gregory J. B
Protocols for Neural Cell Culture, 255-264 (2001)
R L Barker et al.
The Journal of clinical investigation, 88(3), 798-805 (1991-09-01)
Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine. MBP has been localized on damaged helminths and tissues in hypersensitivity diseases including bronchial asthma. The
João Carlos Campanharo et al.
Current microbiology, 46(2), 99-102 (2003-01-10)
For the first time, growth curves are shown for the phytopathogen Xylella fastidiosa on traditional growth media such as PW (periwinkle wilt), BCYE (buffered charcoal yeast extract), and on new ones such as GYE (glutamate yeast extract) and PYE (phosphate
Bo Løfgren et al.
Experimental physiology, 95(1), 140-152 (2009-09-01)
We have found that cardioprotection by l-glutamate mimics protection by classical ischaemic preconditioning (IPC). We investigated whether the effect of IPC involves amino acid transamination and whether IPC modulates myocardial glutamate metabolism. In a glucose-perfused, isolated rat heart model subjected
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