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F8304

Sigma-Aldrich

Flavoxate hydrochloride

≥98% (HPLC), solid

Sinónimos:

3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride, DW-61, Rec-7-0040

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About This Item

Fórmula empírica (notación de Hill):
C24H25NO4 · HCl
Número de CAS:
3717-88-2
Peso molecular:
427.92
Número CE:
223-066-4
Número MDL:
MFCD00072099
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724484
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

solid

color

white

solubilidad

H2O: ~6.6 mg/mL

emisor

Johnson & Johnson

cadena SMILES

Cl[H].CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4

InChI

1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H

Clave InChI

XOEVKNFZUQEERE-UHFFFAOYSA-N

Información sobre el gen

human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622)

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Acciones bioquímicas o fisiológicas

Flavoxate, a flavone derivative[1] and a tertiary-amine antimuscarinic[2] possess antispasmodic properties.[2] It is a strong smooth muscle relaxant[1] that selectively acts on the pelvic region[3] and is used in the symptomatic treatment of overactive bladder (OAB)[1] and incontinence.[2] Post-absorption in the gastrointestinal tract, flavoxate is localized in bladder, liver, and kidney tissues.[1] It mediates the inhibition of phosphodiesterase (PDE) in the urinary bladder.[1] Use of flavoxate aids pain relief in inflammatory disorders of the urinary tract.[3]
L-type Ca2+ (Cav1.2) channel inhibitor

Características y beneficios

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H335

Clasificaciones de peligro

Acute Tox. 4 Oral - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
016K4700

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P Sweeney et al.
European review for medical and pharmacological sciences, 20(17), 3703-3712 (2016-09-22)
Overactive bladder is a syndrome of urinary frequency and urgency, with or without urge incontinence, in the absence of local pathological factors. Since multiple causes are responsible for OAB, it requires proper diagnosis and comprehensive management. For decades, flavoxate is
Ming Lü et al.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 25(2), 169-172 (2004-05-11)
The National Institutes of Health (NIH) category IIIa chronic prostatitis syndromes (non bacterial chronic prostatitis) were common disorders but with few effective therapies. Alpha-blockers and bioflavonoids had recently been reported in randomized controlled trials to improve the symptom of these
Mahesh Attimarad
Journal of basic and clinical pharmacy, 2(1), 53-61 (2010-12-01)
The objective of this study was to develop simple, precise, accurate and sensitive UV spectrophotometric methods for the simultaneous determination of ofloxacin (OFX) and flavoxate HCl (FLX) in pharmaceutical formulations. The first method is based on absorption ratio method, by
Saori Nishijima et al.
The Journal of urology, 173(5), 1812-1816 (2005-04-12)
We examined the mechanism involved in the inhibition of bladder activity in rats by stimulating the rostral pontine reticular formation (RPRF) using carbachol, flavoxate and propiverine, and by analysis of amino acid levels in the lumbosacral cord. A total of
Toshihisa Tomoda et al.
British journal of pharmacology, 146(1), 25-32 (2005-06-21)
The effects of flavoxate hydrochloride (Bladderon, piperidinoethyl-3-methylflavone-8-carboxylate; hereafter referred as flavoxate) on voltage-dependent nifedipine-sensitive inward Ba(2+) currents in human detrusor myocytes were investigated using a conventional whole-cell patch-clamp. Tension measurement was also performed to study the effects of flavoxate on
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