F3554

Anti-Frizzled-10 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-FZD10
• UNSPSC Code: 12352203
• MDL number: MFCD06798443
• Clone: polyclonal
• Species reactivity: human
• Application: IHC (p)
• Citations: 6

Propiedades

• biological source: rabbit
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human kidney, cortex
• UniProt accession no.: Q9ULW2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FZD10(11211) ; mouse ... Fzd10(93897)

Descripción

Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-10, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.

Application

Anti-Frizzled-10 antibody is suitable for immunohistochemistry study (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human kidney, cortex.

Biochem/physiol Actions

Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In humans, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD10, a cell-surface receptor molecules in the Wnt pathway, is expressed during development in embryonic limbs, neural tube, and central nervous system and mediates Wnt signaling. It was reported that FZD10 plays a critical role in the metastasis of synovial sarcoma. Mechanistically, it facilitates the activation of Dvl-Rac1-JNK axis of planar cell polarity (PCP) signaling, with no effect on nuclear β-catenin accumulation and Tcf/Lef reporter activity.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.