F100

Fluspirilene

• Sinónimos: 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one, R 6218
• Fórmula empírica (notación de Hill): C₂₉H₃₁F₂N₃O
• Número de CAS: 1841-19-6
• Peso molecular: 475.57
• Número CE: 217-418-6
• Número MDL: MFCD00055137
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277915
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: solid
• color: white
• solubilidad: DMSO: ≥20 mg/mL; H₂O: insoluble; ethanol: soluble
• emisor: Johnson & Johnson
• temp. de almacenamiento: room temp
• cadena SMILES: Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5
• InChI: 1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)
• Clave InChI: QOYHHIBFXOOADH-UHFFFAOYSA-N
• Información sobre el gen: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Descripción

Aplicación

Fluspirilene has been used as a neuroleptic drug to study its effects on human ether-a-go-go related gene (HERG).[1]

Fluspirilene has been used to study its cytotoxicity effect on malignant glioma.[2]

Acciones bioquímicas o fisiológicas

Fluspirilene has a potential to inhibit the activity of cyclin-dependent kinase 2 (CDK2). It is an effective anti-cancer agent used for treating human hepatocellular carcinoma.[3]

Fluspirilene is a dopamine receptor antagonist.[4] It also acts as a calcium channel blocker.[5] Fluspirilene is an antipsychotic agent and exhibits neuoleptic properties.[5][6] It exhibits therapeutic effects against glioblastoma and Schizophrenia.[6][1]

Características y beneficios

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)