E1032
Anti-EN-RAGE antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-CAGC, Anti-S100 calcium binding protein A12, Anti-S100A12, Anti-p6
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100 μG
709,00 €
709,00 €
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100 μG
709,00 €
About This Item
Código UNSPSC:
12352203
NACRES:
NA.43
709,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Productos recomendados
origen biológico
goat
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
human
técnicas
flow cytometry: 3-10 μg/mL
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... S100A12(6283)
Descripción general
EN-RAGE is a member of the S100/calgranulin superfamily.
Inmunógeno
purified, E. coli-derived recombinant human extracellular RAGE-binding protein.
Aplicación
Anti-EN-RAGE antibody produced in goat is suitable for western blot analysis at a working concentration of 0.1–0.2μg/mL, immunohistochemistry at 5-15μg/mL and flow cytometry at 3-10μg/mL/106 cells.
Acciones bioquímicas o fisiológicas
The gene encodes a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response.[1] It stimulates innate immune cells via binding to receptor for advanced glycation end products (AGER), which activates the MAP-kinase and NF-κ-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also stimulates mast cell degranulation and activation which generates chemokines, histamine and cytokines with leukocyte recruitment to the sites of inflammation.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Zheng Yang et al.
The Journal of allergy and clinical immunology, 119(1), 106-114 (2007-01-09)
The calcium-binding protein S100A12 might provoke inflammation and monocyte recruitment through the receptor for advanced glycation end products. Because inflammation elicited by S100A12 in vivo had characteristics of mast cell (MC) activation, we aimed to define the mechanism. Various MC
Olga V Moroz et al.
BMC biochemistry, 10, 11-11 (2009-04-24)
Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders. S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like
Wei Xing Yan et al.
The Journal of biological chemistry, 283(19), 13035-13043 (2008-02-23)
S100A12 is expressed at sites of acute, chronic, and allergic inflammation. S100 proteins have regions of high sequence homology, but the "hinge" region between the conserved calcium binding domains is structurally and functionally divergent. Because the murine S100A8 hinge domain
A M Cole et al.
FEBS letters, 504(1-2), 5-10 (2001-08-28)
The human airways are protected from pathogenic colonization by a blanket of fluid impregnated with innate antimicrobial effector molecules. Among several previously uncharacterized components, we isolated a peptide that had activity primarily targeting Gram-negative bacteria. We named the peptide 'calcitermin'
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