E0287
Carboxylesterase 1 isoform b human
recombinant, expressed in baculovirus infected BTI insect cells
Sinónimos:
Carboxylesterase 1 human, carboxylesterase, esterase
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Seleccione un Tamaño
1 VIAL
469,00 €
469,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Seleccione un Tamaño
Cambiar Vistas
1 VIAL
469,00 €
About This Item
469,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Productos recomendados
recombinante
expressed in baculovirus infected BTI insect cells
Nivel de calidad
Formulario
liquid
actividad específica
≥500 units/mg protein
concentración
5 mg/mL
peso
(0.5 ml)
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
¿Está buscando productos similares? Visita Guía de comparación de productos
Descripción general
Carboxylesterase (CE) belongs to serine hydrolase family.[1] It is widely present in the human body. Five isoforms of carboxylesterase is present in humans.[2] It is encoded by CES1 gene mapped to 16q22.2 in human chromosome.[3]
Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Aplicación
Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner.[1] It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ.[2]
Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic studies for evaluating pro-drugs and non-CYP pathways of elimination.
Acciones bioquímicas o fisiológicas
Carboxylesterase (CE) is implicated in drug metabolism in liver and hepatic steatosis. Deficiency of CE in humans causes obesity, hyperlipidemia, insulin insensitivity, and cancer.[2]
Definición de unidad
One unti will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37°C
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Resp. Sens. 1
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
¿No ve la versión correcta?
Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Non classical monocytes levels, increased by subcutaneous fat-Secretome, are associated with less Rehospitalization after heart failure admission
Eiras S, et al.
Journal of Cardiovascular Translational Research, 10(1), 16-26 (2017)
A carboxylesterase-selective ratiometric fluorescent two-photon probe and its application to hepatocytes and liver tissues
Park SJ, et al.
Chemical Science, 7(6), 3703-3709 (2016)
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays
Miwa S, et al.
Free Radical Biology & Medicine, 90, 173-183 (2016)
XieMei Tang et al.
Critical reviews in eukaryotic gene expression, 22(3), 179-187 (2012-11-13)
Tuberculosis remains one of the most prevalent and deadly infectious diseases, largely due to the emergence of multidrug-resistant and extensive drug-resistant Mycobacterium tuberculosis, especially the coinfection with HIV. Mycobacterium Ag85 complex (Ag85A, B, and C), with a carboxylesterase consensus sequence
Zhe-Yi Hu et al.
Analytical and bioanalytical chemistry, 405(5), 1695-1704 (2012-12-15)
Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted by esterases to dabigatran (DAB), a direct inhibitor of thrombin. To elucidate the esterase-mediated metabolic pathway of DABE, a high-performance liquid chromatography/mass spectrometry based metabolite identification and semi-quantitative estimation
Filtros activos
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
