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D8946

Sigma-Aldrich

DMH1

≥98% (HPLC), powder, BMP inhibitor

Sinónimos:

4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

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About This Item

Fórmula empírica (notación de Hill):
C24H20N4O
Número de CAS:
1206711-16-1
Peso molecular:
380.44
Número MDL:
MFCD18384963
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
329798883
NACRES:
NA.77

product name

DMH1, ≥98% (HPLC)

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

light yellow to orange

solubilidad

DMSO: 5 mg/mL, clear (warmed)

temp. de almacenamiento

2-8°C

cadena SMILES

CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3

InChI

1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

Clave InChI

JMIFGARJSWXZSH-UHFFFAOYSA-N

Descripción general

DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.

Aplicación

DMH1 has been used for bone morphogenetic protein (BMP) inhibition. It has also been used to block vascular endothelial growth factor (VEGF) signaling.

Acciones bioquímicas o fisiológicas

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Richard H Row et al.
eLife, 7 (2018-06-08)
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs)
Mylah Villacorte et al.
Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)
Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized
José M Martín-Durán et al.
Nature, 553(7686), 45-50 (2017-12-14)
It has been hypothesized that a condensed nervous system with a medial ventral nerve cord is an ancestral character of Bilateria. The presence of similar dorsoventral molecular patterns along the nerve cords of vertebrates, flies, and an annelid has been
Kwang Bo Jung et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(1), 111-122 (2017-09-01)
Human intestinal organoids (hIOs) derived from human pluripotent stem cells (hPSCs) have immense potential as a source of intestines. Therefore, an efficient system is needed for visualizing the stage of intestinal differentiation and further identifying hIOs derived from hPSCs. Here
Silvia Colucci et al.
Blood, 130(19), 2111-2120 (2017-09-03)
The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP
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