The CMR (Carcinogenic, Mutagenic, or Reproductive toxic) classification related to this product is affected by both iron-dextran and phenol. Iron-dextran may potentially be a human carcinogen, while phenol is associated with the risk of causing genetic defects. For detailed information, please refer to Section 11.2 in the Safety Data Sheet (SDS) available at the following link: https://www.sigmaaldrich.com/sds/sigma/d8517?userType=anonymous
D8517
Iron–Dextran
95-105 mg/mL (Iron content), solution
Sinónimos:
Ferric hydroxide dextran complex
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25 ML
163,00 €
100 ML
420,00 €
163,00 €
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25 ML
163,00 €
100 ML
420,00 €
About This Item
163,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
Productos recomendados
origen biológico
synthetic
Nivel de calidad
esterilidad
aseptically filled
Ensayo
95-105 mg/mL (Iron content)
Formulario
solution
contiene
0.5% phenol as preservative
composición
Iron, ~100 mg/mL
color
brown
intervalo de pH útil
4 - 6.5
temp. de almacenamiento
room temp
cadena SMILES
[Fe].[S](=O)(=O)(O)O
InChI
1S/Fe.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)
Clave InChI
MVZXTUSAYBWAAM-UHFFFAOYSA-N
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Aplicación
Otras notas
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Carc. 1B - Skin Sens. 1
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Natacha E Piloni et al.
Toxicology, 314(1), 174-182 (2013-10-15)
An in vivo model in rat was developed by intraperitoneally administration of Fe-dextran to study oxidative stress triggered by Fe-overload in rat brain. Total Fe levels, as well as the labile iron pool (LIP) concentration, in brain from rats subjected
Yonggang Gao et al.
Journal of ethnopharmacology, 145(1), 254-260 (2012-11-14)
Danshen (Salvia miltiorrhiza) has been widely prescribed in traditional folk medicine for treatment of hepatic and cardiovascular diseases in China and other Asian countries for several hundred years. Sixty male mice were randomly divided into five groups: control, iron overload
Raymond J Bergeron et al.
Journal of medicinal chemistry, 51(13), 3913-3923 (2008-06-07)
A series of iron-clearing efficiencies (ICEs), ferrokinetics, and toxicity studies for ( S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid (deferitrin, 1), ( S)-4,5-dihydro-2-[2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid ( 2), and (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid ( 3) are reported. The ICEs in rodents are shown to be dose-dependent and saturable for
Zachariah DeFilipp et al.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 9(1), 129-132 (2012-08-08)
Iron deficiency is a major postoperative complication of Roux-en-Y gastric bypass surgery. Oral replacement can fail to correct the deficiency. Thus, recourse to parenteral iron administration might be necessary. Our objective was to evaluate the effectiveness and safety of a
Markus R Jahn et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 78(3), 480-491 (2011-03-29)
The treatment of iron deficiency anemia with polynuclear iron formulations is an established therapy in patients with chronic kidney disease but also in other disease areas like gastroenterology, cardiology, oncology, pre/post operatively and obstetrics' and gynecology. Parenteral iron formulations represent
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Is the CMR danger related to the presence of Phenol as a preservative or other components ? and/or Iron-dextran itself ?
1 respuesta-
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How can I determine the shelf life / expiration / retest date of this product?
1 respuesta-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf¿Le ha resultado útil?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 respuesta-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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I am interested in the dextran concentration and the molcular weight of the dextran of the iron dextran solution (D8517)
1 respuesta-
The detran concentration is not determined for this product. The iron particles are coated with dextran by Ven der Waals forces, allowing them to remain in solution. The dextran used in the preparation is partically hydrolyzed and has an approximate molecular weight of 5000 daltons.
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Provide the information about concentration for this product and further solubility.
1 respuesta-
The product is provided as a 100 mg iron/ml solution in water, containing 0.5% phenol as a preservative. It can be further diluted in water or buffer.
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