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D7910

Sigma-Aldrich

3,4-Dichloroisocoumarin

serine protease inhibitor

Sinónimos:

3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one

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About This Item

Fórmula empírica (notación de Hill):
C9H4Cl2O2
Número de CAS:
51050-59-0
Peso molecular:
215.03
Beilstein:
6802625
Número MDL:
MFCD00036960
Código UNSPSC:
12352202
ID de la sustancia en PubChem:
24278386
NACRES:
NA.77

Nivel de calidad

200

Análisis

≥98% (TLC)

formulario

powder

solubilidad

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

temp. de almacenamiento

2-8°C

cadena SMILES

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

Clave InChI

SUGXUUGGLDCZKB-UHFFFAOYSA-N

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Aplicación

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.

Otras notas

Effective concentration 5-100 μM.

Cantidad

Half-life = 20 min at pH 7.5.

Sustratos

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301,H315,H319,H335

Clasificaciones de peligro

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Diego López León et al.
iScience, 23(3), 100932-100932 (2020-03-11)
Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show
Premkumari Kumarathasan et al.
Particle and fibre toxicology, 15(1), 34-34 (2018-08-12)
There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a
Anežka Tichá et al.
Cell chemical biology, 24(12), 1523-1536 (2017-11-07)
Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is currently untapped. Here, we
K S Lang et al.
Cell death and differentiation, 11(2), 231-243 (2003-11-15)
Erythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of nucleated cells. However, following increase of cytosolic Ca(2+) activity, erythrocytes undergo cell shrinkage, cell membrane blebbing and breakdown of phosphatidylserine asymmetry, all features typical for apoptosis in nucleated cells.
Brett M Babin et al.
Cell chemical biology, 29(5), 897-909 (2021-10-03)
The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis of the mycobacterial cell envelope.
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