C6613
Anti-Cdc7 Kinase antibody, Mouse monoclonal
clone DCS-341, purified from hybridoma cell culture
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About This Item
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origen biológico
mouse
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
DCS-341, monoclonal
formulario
buffered aqueous solution
reactividad de especies
human
concentración
~2 mg/mL
técnicas
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.4 μg/mL using total cell extract of A431 cells
isotipo
IgG1
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CDC7(8317)
Descripción general
Anti-Cdc7 Kinase antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the DCS-341 hybridoma produced by the fusion of mouse myeloma cells (NS2) and splenocytes from BALB/c mice immunized with full length human Cdc7 kinase. Cell division cycle 7-related protein kinase(CDC7) is an enzyme encoded by the CDC7 gene in humans. It is highly expressed in diffuse large B cell lymphoma (DLBCL). Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. CDC7 shares nearly 45% identity with yeast Cdc7 kinase in the kinase domain.
Inmunógeno
full-length human Cdc7 kinase.
Aplicación
Anti-Cdc7 Kinase antibody, Mouse monoclonal has been used in:
- enzyme-linked immunosorbent assay (ELISA)
- immunoblotting
- immunoprecipitation
- immunocytochemistry.
Acciones bioquímicas o fisiológicas
Cell division cycle 7-related protein kinase (CDC7) in addition to its role in chromosome structure maintenance and repair, is also involved in meiosis and checkpoint responses.
Cell division cycle 7-related protein kinase(CDC7) is a serine-threonine essential kinase required for the initiation of DNA replication and is involved in regulation of the cell cycle. It is high expressed in diffuse large B cell lymphoma (DLBCL). Loss of Cdc7 kinase expression results in retarded growth at both cellular and whole body levels, with especially profound impairment of germ cell development. It inhibits genotoxin-induced apoptosis and increases survival in cancer cells. It may play an important role in the development and progression of colorectal cancer. Depletion of Cdc7 induces cancer cell death regardless of its p53 status. It can also interact with and phosphorylate Claspin.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Michael D Rainey et al.
Cell cycle (Georgetown, Tex.), 12(10), 1560-1568 (2013-04-20)
Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can also interact with and phosphorylate Claspin. In this
Hai-Jun Chen et al.
World journal of gastroenterology, 19(20), 3130-3133 (2013-05-30)
To detect the expression of huCdc7 in colorectal cancer. The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. The
Jung Min Kim et al.
Mutation research, 532(1-2), 29-40 (2003-12-04)
Cdc7 kinase plays an essential role in firing of replication origins by phosphorylating components of the replication complexes. Cdc7 kinase has also been implicated in S phase checkpoint signaling downstream of the ATR and Chk1 kinases. Inactivation of Cdc7 in
An Ning Cheng et al.
Cancer letters, 337(2), 218-225 (2013-05-21)
Cdc7-Dbf4 kinase (Dbf4-dependent kinase, DDK) is an essential factor of DNA replication and DNA damage response (DDR), which is associated with tumorigenesis. However, Cdc7 expression has never been associated to the outcome of oral squamous cell carcinoma (OSCC) patients, and
Cdc7 kinase complex: a key regulator in the initiation of DNA replication
Masai H and Arai KI
Journal of Cellular Physiology, 190(3), 287-296 (2002)
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