C2743

Cytochalasin B from Drechslera dematioidea

Ready Made Solution, 10 mg/mL in DMSO

• Sinónimos: Phomin
• Fórmula empírica (notación de Hill): C₂₉H₃₇NO₅
• Número CAS: 14930-96-2
• Peso molecular: 479.61
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 329774749
• MDL number: MFCD00077704
• Beilstein/REAXYS Number: 1096207

Propiedades

• Quality Segment: 200
• form: ready-to-use solution
• concentration: 10 mg/mL in DMSO
• antibiotic activity spectrum: fungi
• application(s): advanced drug delivery
• mode of action: cell membrane | interferes
• storage temp.: −20°C
• SMILES string: C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• InChI key: GBOGMAARMMDZGR-TYHYBEHESA-N

Descripción

Application

Cytochalasin B is used to inhibit sugar transport in fibroblasts , decrease cytoskeletal actin and myosin in rabbit neutrophils , and to stimulate B lymphocytes .

Cytochalasin B from Drechslera dematioidea has been used:

• to block cytokinesis, to obtain binucleated cells
• as a specific glucose transporter inhibitor
• to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells

Biochem/physiol Actions

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H302,H330
• Indicaciones de precaución: P260 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): 185.0 °F - closed cup - Solvent
• Punto de inflamación (°C): 85 °C - closed cup - Solvent
• EPI (equipos de protección individual): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter