C2743

Cytochalasin B from Drechslera dematioidea

Ready Made Solution, 10 mg/mL in DMSO

• Sinónimos: Phomin
• Fórmula empírica (notación de Hill): C₂₉H₃₇NO₅
• Número de CAS: 14930-96-2
• Peso molecular: 479.61
• Beilstein: 1096207
• Número MDL: MFCD00077704
• Código UNSPSC: 51102829
• ID de la sustancia en PubChem: 329774749
• NACRES: NA.85

Propiedades

• Nivel de calidad: 200
• formulario: solution
• concentración: 10 mg/mL in DMSO
• espectro de actividad antibiótica: fungi
• Modo de acción: cell membrane | interferes
• temp. de almacenamiento: −20°C
• cadena SMILES: C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• Clave InChI: GBOGMAARMMDZGR-TYHYBEHESA-N

Descripción

Aplicación

Cytochalasin B from Drechslera dematioidea has been used:

• to block cytokinesis, to obtain binucleated cells
• as a specific glucose transporter inhibitor
• to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells

Cytochalasin B is used to inhibit sugar transport in fibroblasts , decrease cytoskeletal actin and myosin in rabbit neutrophils , and to stimulate B lymphocytes .

Acciones bioquímicas o fisiológicas

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H302,H330
• Consejos de prudencia: P260 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 185.0 °F - closed cup - Solvent
• Punto de inflamabilidad (°C): 85 °C - closed cup - Solvent
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter