C2436
Cytochrome c from Saccharomyces cerevisiae
≥85% based on Mol. Wt. 12,588 basis
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About This Item
Productos recomendados
origen biológico
Saccharomyces cerevisiae
Análisis
≥85% based on Mol. Wt. 12,588 basis
formulario
powder
mol peso
12,588 Da
técnicas
cell based assay: suitable
solubilidad
water: 10 mg/mL, clear, red to red-brown (dark red)
Nº de acceso UniProt
aplicaciones
cell analysis
temp. de almacenamiento
−20°C
Información sobre el gen
Saccharomyces cerevisiae ... CYC1(853507)
Descripción general
Cytochrome c (Cytc) comprises 104 amino acids and is a nuclear-encoded mitochondrial protein. This peripheral membrane protein is in spherical shape and has a molecular weight of 12,000 Da.
Aplicación
Cytochrome c from Saccharomyces cerevisiae has been used in oocyte injection to induce caspase-3 activation and p38 MAPK (mitogen-activated protein kinase). It has also been used to analyze the aerobic reactions of nitric oxide.
Acciones bioquímicas o fisiológicas
Cytochrome c (Cytc) participates in mitochondrial electron transport and intrinsic type II apoptosis. It plays a key role in aerobic energy production. This multi-functional enzyme serves as a single electron carrier. Cytc helps in the formation of the apoptosome.
The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen. Tracking cellular localization of cytochrome c in S. cerervisiae demonstrates that mitochondria are strongly involved in programmed cell death, a process very similar to apoptosis in higher organisms.
Calidad
Care has been taken to maintain the native form of the protein. It has not been artificially oxidized or reduced during purification. Contains variable amounts of reduced cytochrome c.
Nota de preparación
Prepared without using TCA.
Otras notas
View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.
Aplicación
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock
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PLoS ONE, 10(9) (2015)
The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis
Huttemann M, et al.
Mitochondrion, 11(3), 369-369 (2011)
Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite
SHARPE MA and Cooper CE
The Biochemical Journal, 332(1), 9-19 (1998)
Membrane Proteins
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Chromatograms
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