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Merck

B9935

BMS-345541

≥98% (HPLC), powder

Sinónimos:

N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

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5 MG

262,00 €

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1010,00 €

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Fórmula empírica (notación de Hill):
C14H17N5 · HCl
Número CAS:
547757-23-3
Peso molecular:
291.78
NACRES:
NA.77
PubChem Substance ID:
24724429
UNSPSC Code:
12352200
MDL number:
MFCD07784499
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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InChI key

MIDKPVLYXNLFGZ-UHFFFAOYSA-N

SMILES string

Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1

InChI

1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 18 mg/mL, H2O: insoluble

originator

Bristol-Myers Squibb

storage temp.

2-8°C

Quality Level

100

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Este artículo
SML2410SML2331SML1200
BMS-345541 ≥98% (HPLC), powder

Sigma-Aldrich

B9935

BMS-345541

ABC99 ≥98% (HPLC)

Sigma-Aldrich

SML2410

ABC99

Perospirone hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML2331

Perospirone hydrochloride

RO8191 ≥98% (HPLC)

Sigma-Aldrich

SML1200

RO8191

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 18 mg/mL, H2O: insoluble

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 0.5 mg/mL, clear (warmed)

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

-

Application

BMS-345541 has been used:
  • as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells[1]
  • as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts[2]
  • as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma cells[3]

Biochem/physiol Actions

BMS-345541 is an IKB kinase (IKK) allosteric site inhibitor.
BMS-345541 possesses anti-inflammatory properties.[4] It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines.[5] BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.[2]

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000192429
0000192430
0000150605
0000150605
0000192430

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James R Burke et al.
The Journal of biological chemistry, 278(3), 1450-1456 (2002-10-31)
The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent ubiquitination and proteolysis of I kappa B alpha, which then releases NF-kappa B to promote gene transcription. The multisubunit I kappa
Neety Sahu et al.
JCI insight, 7(20) (2022-10-05)
No disease-modifying drug exists for osteoarthritis (OA). Despite success in animal models, candidate drugs continue to fail in clinical trials owing to the unmapped interpatient heterogeneity and disease complexity. We used a single-cell platform based on cytometry by time-of-flight (cyTOF)
Christina Ward et al.
Tissue barriers, 3(1-2), e982424-e982424 (2015-04-04)
NF-κB (p50/p65) is the best characterized transcription factor known to regulate cell responses to inflammation. However, NF-κB is also constitutively expressed. We used inhibitors of the classical NF-κB signaling pathway to determine whether this transcription factor has a role in
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
Rae, et al.
Science immunology, 7, eabn3800-eabn3800 (2023)
Zhiyang Chen et al.
The Journal of experimental medicine, 216(1), 152-175 (2018-12-12)
Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their
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