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B0189

Sigma-Aldrich

Casticin

from Vitex trifolia, ≥98% (HPLC)

Sinónimos:

Casticine, Quercetagetin 3,6,7,4′-tetramethyl ether, Vitexicarpin

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About This Item

Fórmula empírica (notación de Hill):
C19H18O8
Número de CAS:
479-91-4
Peso molecular:
374.34
Código UNSPSC:
12352200
NACRES:
NA.25

origen biológico

Vitex trifolia

Análisis

≥98% (HPLC)

formulario

powder

solubilidad

ethanol: 1 mg/mL, clear, colorless to light yellow

aplicaciones

metabolomics
vitamins, nutraceuticals, and natural products

temp. de almacenamiento

2-8°C

InChI

1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3

Clave InChI

PJQLSMYMOKWUJG-UHFFFAOYSA-N

Descripción general

Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb. It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.

Aplicación

Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.

Acciones bioquímicas o fisiológicas

Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.
Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Flavonoids from the aerial parts of Inula japonica
Qin J, et al.
Chinese Journal of Natural Medicines, 8, 257-259 (2010)
Lihua He et al.
Oncology reports, 29(1), 103-108 (2012-10-16)
Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC
Yuan Hu et al.
The Journal of pharmacy and pharmacology, 59(9), 1307-1312 (2007-09-22)
The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-SCREEN assessment system), as well as the
Donna E Webster et al.
Biochemical pharmacology, 81(1), 170-177 (2010-09-22)
Vitex agnus-castus (VAC) has been used since ancient Greek times and has been shown clinically to be effective for the treatment of pre-menstrual syndrome. However, its mechanism of action has only been partially determined. Compounds, fractions, and extracts isolated from
Jun Yang et al.
World journal of gastroenterology, 17(38), 4298-4307 (2011-11-18)
To investigate the apoptotic activities of casticin in hepatocellular carcinoma (HCC) cells and its molecular mechanisms. PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of casticin on the growth of cells was detected by
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