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A9719

Sigma-Aldrich

Arachidonyl-2′-chloroethylamide hydrate

≥97% (HPLC), oil

Sinónimos:

ACEA

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About This Item

Fórmula empírica (notación de Hill):
C22H36ClNO · xH2O
Número de CAS:
220556-69-4
Peso molecular:
365.98 (anhydrous basis)
Número MDL:
MFCD02683581
Código UNSPSC:
51111800
ID de la sustancia en PubChem:
24891489
NACRES:
NA.77

Nivel de calidad

100

Análisis

≥97% (HPLC)

formulario

oil

control farmacológico

regulated under CDSA - not available from Sigma-Aldrich Canada

condiciones de almacenamiento

desiccated

color

brown-red

solubilidad

DMSO: soluble
H2O: insoluble

temp. de almacenamiento

−20°C

cadena SMILES

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl

InChI

1S/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-

Clave InChI

SCJNCDSAIRBRIA-DOFZRALJSA-N

Información sobre el gen

mouse ... Cnr1(12801) , Cnr2(12802)
rat ... Cnr1(25248)

Acciones bioquímicas o fisiológicas

Potent and selective neuronal CB1 cannabinoid receptor agonist.

Características y beneficios

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Precaución

Photosensitive; store under argon or nitrogen.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yahya I Asiri et al.
Anesthesia and analgesia, 127(2), 548-555 (2017-10-11)
Development of new analgesics is limited by shortcomings of existing preclinical screening assays such as wide variations in response, suitability for a narrow range of analgesics, and propensity to induce tissue damage. Our aim was to determine the feasibility of
Akiko Tsuchida et al.
Scientific reports, 8(1), 7017-7017 (2018-05-08)
GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of GalNAc-DSLc4 in malignant properties of RCCs, we identified B4GalNAc-T2 as a responsible gene for the synthesis of
C J Hillard et al.
The Journal of pharmacology and experimental therapeutics, 289(3), 1427-1433 (1999-05-21)
Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. We
Chris L Baker et al.
British journal of pharmacology, 142(8), 1361-1367 (2004-07-28)
The vasoactive effects of the synthetic cannabinoid (CB) arachidonyl-2-chloroethylamide (ACEA) was tested in the knee joints of urethane-anaesthetised rats. Experiments were also performed to determine whether these vasomotor responses could be blocked by the selective CB(1) receptor antagonists AM251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide)
Tamás Oláh et al.
The Journal of physiology, 594(24), 7381-7398 (2016-10-28)
Marijuana was found to cause muscle weakness, although the exact regulatory role of its receptors (CB1 cannabinoid receptor; CB1R) in the excitation-contraction coupling (ECC) of mammalian skeletal muscle remains unknown. We found that CB1R activation or its knockout did not
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