A9227

ABT-491 hydrochloride

≥98% (HPLC), active platelet-activating factor (PAF) receptor antagonist, solid

• Sinónimos: 4-Ethynyl-N,N-dimethyl-3-[3-fluoro-4-[(2-methyl-1H-imidazo-[4,5-c]pyridin-1-yl)methyl]benzoyl]-1H-indole-1-carboxamide hydrochloride, A-137491
• Fórmula empírica (notación de Hill): C₂₈H₂₂N₅O₂F · HCl
• Número CAS: 189689-94-9
• Peso molecular: 515.97
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724404
• NACRES: NA.77
• MDL number: MFCD00945301
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Propiedades

• Nombre del producto: ABT-491 hydrochloride, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to beige
• mp: 170-178 °C (lit.)
• solubility: H₂O: freely soluble 22 mg/mL
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c5c(cccc15)C#C
• InChI: 1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H
• InChI key: AWRGBOKANQBIBM-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Highly potent, selective and orally active platelet-activating factor (PAF) receptor antagonist. K_i = 0.6 nM in human platelets.

Features and Benefits

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)