A6671

Actinonin

≥98% (TLC), powder, leucine aminopeptidase inhibitor

• Sinónimos: 3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
• Fórmula empírica (notación de Hill): C₁₉H₃₅N₃O₅
• Número CAS: 13434-13-4
• Peso molecular: 385.50
• NACRES: NA.77
• PubChem Substance ID: 24278232
• UNSPSC Code: 12352200
• MDL number: MFCD00080257
• Beilstein/REAXYS Number: 1555250
• Assay: ≥98% (TLC)
• Form: powder

Propiedades

• Nombre del producto: Actinonin,
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: ethanol: 50 mg/mL, clear, colorless
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
• InChI: 1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
• InChI key: XJLATMLVMSFZBN-UHFFFAOYSA-N
• Gene Information: human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)

Descripción

General description

Chemical structure: peptide

Application

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.

Biochem/physiol Actions

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Gloves, type N95 (US)