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A1640

Sigma-Aldrich

Adenosine 5′-O-thiomonophosphate dilithium salt

≥98%

Sinónimos:

5′-AMPS

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About This Item

Fórmula empírica (notación de Hill):
C10H12Li2N5O6PS
Número de CAS:
93839-85-1
Peso molecular:
375.15
Número MDL:
MFCD00042996
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
24890572
NACRES:
NA.51

Análisis

≥98%

formulario

powder

temp. de almacenamiento

−20°C

cadena SMILES

[Li+].[Li]SP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C10H14N5O6PS.2Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(21-10)1-20-22(18,19)23;;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,23);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

Clave InChI

FZXPFDFAEUBVHA-IDIVVRGQSA-L

Categorías relacionadas

Aplicación

Adenosine 5′′-O-thiomonophosphate (5′-AMPS) is a 5′-O-thiophosphate which along with adenosine 5′-O-(2-thiodiphosphate) and adenosine 5′-O-(3-thiotriphosphate) can act as inhibitors of phosphohydrolases. AMPS is a substrate for smooth muscle endothelial ecto-5′-nucleotidase. 5′APMS is a stimulator of 5-lipoxygenase activity of rat polymorphonuclear (PMN) leukocytes. Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5′-O-phosphorothioates such as 5′-AMPS to nucleoside 5′-O-phosphates.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H371

Clasificaciones de peligro

Acute Tox. 4 Oral - STOT SE 2

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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J D Pearson et al.
The Biochemical journal, 230(2), 503-507 (1985-09-01)
We compared the properties of the ectonucleotidases (nucleoside triphosphatase, EC 3.6.1.15; nucleoside diphosphatase, EC 3.6.1.6; 5'-nucleotidase, EC 3.1.3.5) in intact pig aortic smooth-muscle cells in culture with the properties that we previously investigated for ectonucleotidases of aortic endothelial cells [Cusack
Magdalena Ozga et al.
The Journal of biological chemistry, 285(52), 40809-40818 (2010-10-14)
Nucleoside 5'-O-phosphorothioates are formed in vivo as primary products of hydrolysis of oligo(nucleoside phosphorothioate)s (PS-oligos) that are applied as antisense therapeutic molecules. The biodistribution of PS-oligos and their pharmacokinetics have been widely reported, but little is known about their subsequent
D Denis et al.
Archives of biochemistry and biophysics, 273(2), 592-596 (1989-09-01)
The stable nucleotide analog guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) was found to be a very potent activator of 5-lipoxygenase in cell-free preparations from rat polymorphonuclear (PMN) leukocytes, causing a 10-fold stimulation of arachidonic acid oxidation at concentrations as low as
Adenosine 5'-phosphorothioate. A nucleotide analog that is a substrate, competitive inhibitor, or regulator of some enzymes that interact with adenosine 5'-phosphate.
A W Murray et al.
Biochemistry, 7(11), 4023-4029 (1968-11-01)
D J Montague et al.
European journal of biochemistry, 139(3), 529-534 (1984-03-15)
Adenosine diphosphatase (ADPase) activity and ATPase activity were assayed in rat liver mitochondria and outer mitochondrial membrane preparations with [beta-32P]ADP and [gamma-32P]ATP as substrates. Inhibition studies were performed with the mitochondrial ATPase inhibitor oligomycin and the adenine nucleotide transport inhibitor

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