451M-1

h-Caldesmon (hHCD) Mouse Monoclonal Antibody

• Código UNSPSC: 12352203

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: diluted ascites fluid
• tipo de anticuerpo: primary antibodies
• clon: hHCD, monoclonal
• descripción: For In Vitro Diagnostic Use in Select Regions
• formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL concentrate (451M-14); vial of 0.1 mL concentrate Research Use Only (451M-14-RUO); vial of 0.5 mL concentrate (451M-15); vial of 1.0 mL concentrate (451M-16); vial of 1.0 mL concentrate Research Use Only (451M-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (451M-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (451M-17); vial of 7.0 mL pre-dilute ready-to-use (451M-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (451M-18-RUO)
• fabricante / nombre comercial: Cell Marque^™
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)
• isotipo: IgG1
• control: bladder, colon, leiomyoma, smooth muscle tumors, stomach
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: cytoplasmic

Descripción

Descripción general

Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer. In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.

Calidad

IVD

IVD

IVD

RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2