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114R-1

Sigma-Aldrich

CD14 (EPR3653) Rabbit Monoclonal Primary Antibody

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1 ML
185,00 €
0.1 ML
207,00 €
0.5 ML
535,00 €
7 ML
572,00 €
1 ML
836,00 €

185,00 €


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1 ML
185,00 €
0.1 ML
207,00 €
0.5 ML
535,00 €
7 ML
572,00 €
1 ML
836,00 €

About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

185,00 €


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origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EPR3653, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (114R-14)
vial of 0.5 mL concentrate (114R-15)
bottle of 1.0 mL predilute (114R-17)
vial of 1.0 mL concentrate (114R-16)
bottle of 7.0 mL predilute (114R-18)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotipo

IgG

control

tonsil

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic, membranous

Información sobre el gen

human ... CD14(929)

Descripción general

CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Anti-CD14 antibody labels Kupffer cells in liver sinusoids. In lymphoid tissues, dendritic cells are distinctly stained. Most other normal tissues are negative. This antibody labels monocyte-macrophages and Langerhans cells in Langerhans cell histiocytosis. Tumor cells are positive in monocytic leukemia and true histiocytic lymphomas for CD14. Sinusoidal histiocytes express CD14 and CD 169, whereas most of the other monocyte-derived cells in reactive lymph node lack these markers. Anti-CD14 labels numerous diffuse large B-cell lymphomas and splenic marginal zone lymphoma but not in other B-cell lymphomas.

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

CD14 Positive Control Slides, Product No. 114S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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A T Larregina et al.
Nature immunology, 2(12), 1151-1158 (2001-11-10)
Epidermal Langerhans cells (LCs) show extraordinary immunostimulatory capacity and play a key role in the initiation and regulation of immune responses. Studies of LC biology are currently the focus of efforts to engineer immune responses and to better understand the
B Steiniger et al.
Immunology, 92(2), 307-316 (1998-01-01)
The microanatomical structure of human and rat splenic white pulp is compared, with special emphasis on the localization of the marginal zone occupied by immunoglobulin M (IgM)+ IgD-/dull B lymphocytes and its specialized macrophages. Our study reveals that in contrast
Cheng-Hsiang Hsiao et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 105(9), 701-707 (2006-09-09)
Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder that usually presents as cervical lymphadenopathy. Extranodal involvement occurs in up to 40% of patients. The disease is most prevalent in blacks and rare in Asians. This study analyzed the characteristics
C D Gregory et al.
Apoptosis : an international journal on programmed cell death, 4(1), 11-20 (2003-11-25)
In addition to its role as a mediator of innate pro-inflammatory responses following bacterial lipopolysaccharide (LPS) binding, the 55kDa glycosyl-phosphatidylinositol-linked macrophage plasma membrane glycoprotein CD14 is now also known to play a role in phagocytic clearance of apoptotic cells. Although
P J Buckley et al.
The American journal of pathology, 128(3), 505-520 (1987-09-01)
Macrophages (M phi s) are an important component of the immune response and mediate numerous other functions. Phenotypic and functional subsets of circulating monocytes have been described, but few similar studies have analyzed M phi s in human tissues. By

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