Unfortunately, this material has not been evaluated for cell permeability.
02711
Hydroxypyruvic acid phosphate lithium salt
≥95% (HPLC)
Sinónimos:
2-oxo-3-(phosphonooxy)propanoic acid, Phosphohydroxypyruvic acid
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10 MG
116,00 €
50 MG
465,00 €
116,00 €
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10 MG
116,00 €
50 MG
465,00 €
About This Item
Fórmula empírica (notación de Hill):
C3H5O7P · xLi+
Número de CAS:
Peso molecular:
184.04 (free acid basis)
Número MDL:
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
NACRES:
NA.25
116,00 €
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grado
for analytical purposes
Nivel de calidad
Ensayo
≥95% (HPLC)
composición
lithium, 5.0-14.0% ICP
impurezas
≤8.0% water
temp. de almacenamiento
−20°C
cadena SMILES
O=C(O)C(COP(O)(O)=O)=O
O=C(O)C(COP(O)(O)=O)=O
InChI
1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)
Clave InChI
LFLUCDOSQPJJBE-UHFFFAOYSA-N
Categorías relacionadas
Acciones bioquímicas o fisiológicas
L-Serine may be derived from four possible sources: dietary intake, biosynthesis from the glycolytic intermediate 3-phosphoglycerate, from glycine, and by protein and phospholipid degradation. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted into phosphohydroxy-pyruvate, in a reaction catalyzed by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and, finally, phosphoserine is converted into L-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three synthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function; e.g. Alzheimer′s disease[1], schizophrenia[2][3], heart failure[4], and juvenile myoclonic epilepsy[5].
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Dermal - Acute Tox. 4 Oral
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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H Nørrelund et al.
Journal of internal medicine, 260(1), 11-21 (2006-06-23)
It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism.
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Archives of general psychiatry, 60(6), 572-576 (2003-06-11)
The hypofunction of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors has been implicated in the pathophysiology of schizophrenia. Several lines of evidence suggest that D-serine may function as an endogenous agonist of the glycine site of the NMDA receptor. The
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