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Y0000359

Acebutolol impurity B

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide, Diacetolol

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10 MG
166,00 €

166,00 €


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10 MG
166,00 €

About This Item

Fórmula empírica (notación de Hill):
C16H24N2O4
Número de CAS:
Peso molecular:
308.37
Código UNSPSC:
41116107
NACRES:
NA.24

166,00 €


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grado

pharmaceutical primary standard

familia API

acebutolol

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

N(C(C)C)CC(O)COc1c(cc(cc1)NC(=O)C)C(=O)C

InChI

1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

Clave InChI

AWOGXJOBNAWQSF-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

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M J Boutroy et al.
European journal of clinical pharmacology, 30(6), 737-739 (1986-01-01)
The concentrations of acebutolol and of its main active metabolite diacetolol in milk and plasma were studied in 7 hypertensive mothers treated with acebutolol, a cardioselective beta-adrenoceptor blocking agent. Clinical monitoring on their newborn babies was also done, as well
High-performance liquid chromatographic determination of diacetolol enantiomers.
M Piquette-Miller et al.
Journal of chromatography, 533, 300-303 (1990-11-30)
Jun Shik Choi et al.
Archives of pharmacal research, 25(4), 541-545 (2002-09-07)
Pharmacokinetic characteristics of acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay.
S Abolfazl Mostafavi et al.
International journal of pharmaceutics, 255(1-2), 81-86 (2003-04-04)
Acebutolol (AC) is a chiral beta-adrenergic receptor-blocking agent, which has been shown to be clinically effective in hypertension. The plasma concentration-time profiles of AC exhibit two peaks following oral administration of racemate for both R- and S-enantiomers. In the present
J Szymura-Oleksiak et al.
Chirality, 11(4), 267-271 (1999-05-04)
A stereoselective direct liquid chromatographic method for assay of the enantiomers of the beta-adrenergic blocker acebutolol (AC) and its active metabolite, diacetolol (DC), in human serum was developed. The assay is based on extraction with ethyl acetate and separation of

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