PHR1731

Nitisinone

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Nitisinone, 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione, NTBC, Nitisone, SC 0735
• Fórmula empírica (notación de Hill): C₁₄H₁₀F₃NO₅
• Número de CAS: 104206-65-7
• Peso molecular: 329.23
• Número MDL: MFCD01752192
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823580
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• familia API: nitisinone
• CofA: current certificate can be downloaded
• envase: pkg of 1 g
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: -10 to -25°C
• cadena SMILES: [O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
• InChI: 1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
• Clave InChI: OUBCNLGXQFSTLU-UHFFFAOYSA-N
• Información sobre el gen: human ... HPD(3242)

Descripción

Descripción general

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Nitisinone is a medication, effectively used for the treatment and maintainence of alkaptonuria, an autosomal recessive disease. Its mode of action involves the inhibition of second enzyme in the tyrosine pathway, 4-hydroxyphenylpyruvate dioxygenase that produces HGA from 4-hydroxyphenylpyruvate.[1][2]

Aplicación

Nitisinone may be used as a pharmaceutical reference standard for the quantification of the analyte in phamraceutical formulations using high-performance liquid chromatography technique.[3]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

Nitisinone is a competitive and reversible inhibitor of 4-Hydroxyphenylpyruvate oxidase (dioxygenase).

Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0575 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable