PHR1722

Triamterene

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Triamterene, 2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine
• Fórmula empírica (notación de Hill): C₁₂H₁₁N₇
• Número de CAS: 396-01-0
• Peso molecular: 253.26
• Número CE: 206-904-3
• Número MDL: MFCD00006708
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823575
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to Ph. Eur. Y0000837; traceable to USP 1680007
• familia API: triamterene
• CofA: current certificate can be downloaded
• envase: pkg of 400 mg
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
• InChI: 1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
• Clave InChI: FNYLWPVRPXGIIP-UHFFFAOYSA-N
• Información sobre el gen: human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)

Descripción

Descripción general

Triamterene is a potassium-sparing diuretic,[1] which exhibits antihypertensive activity.[2] It is used in combination with thiazide deuretic, such as benzthiazide for treating hypertension and edema associated with mild to moderate congestive heart failure.[1]

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Triamterene may be used as a secondary pharma standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.[2][1]

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA7397 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable