This standard is a prepared solution of 5-chloro-2-methyl-2H-isothiazolin-3-one (CMIT) and 2-methyl-2H-isothiazol-3-one (MIT) in water, with a certified purity by HPLC analysis reported for each analyte in the lot-specific Certificate of Analysis. This standard is suitable for use in HPLC analysis, and the method used for the purity assay is detailed in the Certificate of Analysis.
PHR1597
CMIT/MIT
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
5-chloro-2-methyl-2h-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one
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1 ML
96,80 €
96,80 €
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1 ML
96,80 €
About This Item
Código UNSPSC:
41116107
NACRES:
NA.24
96,80 €
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grado
certified reference material
pharmaceutical secondary standard
Nivel de calidad
familia API
cmit/mit
Formulario
liquid
CofA
current certificate can be downloaded
envase
ampule of 1 mL
aplicaciones
pharmaceutical (small molecule)
temp. de almacenamiento
2-30°C
Descripción general
Pharmaceutical secondary standard for applications in quality control, provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
CMIT/MIT is an isothiazolone biocide having a 3:1 ratio of CMIT and MIT, widely used for its broad-spectrum action against microbes, algae, and fungi. It is one of the active ingredients of humidifier disinfectants and a commonly used preservative in industrial products such as cosmetics, paints, adhesives and detergents.[1][2][3][4][5]
CMIT/MIT is an isothiazolone biocide having a 3:1 ratio of CMIT and MIT, widely used for its broad-spectrum action against microbes, algae, and fungi. It is one of the active ingredients of humidifier disinfectants and a commonly used preservative in industrial products such as cosmetics, paints, adhesives and detergents.[1][2][3][4][5]
Aplicación
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nota de análisis
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Otras notas
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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The mechanism of action of isothiazolone biocides
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PowerPlant Chemistry, 9(1), 14-14 (2007)
Refined exposure assessment for three active ingredients of humidifier disinfectants
Lee JH, et al.
Environmental Engineering Research, 18(4), 253-257 (2013)
Risk Assessment of 5-Chloro-2-Methylisothiazol-3 (2H)-One/2-Methylisothiazol-3 (2H)-One (CMIT/MIT) Used as a Preservative in Cosmetics
Kim MK, et al.
Toxicological Research, 35(2), 103-103 (2019)
Fatal misuse of humidifier disinfectants in Korea: importance of screening risk assessment and implications for management of chemicals in consumer products
Lee JH, et al.
PowerPlant Chemistry, 9(1), 14-14 (2012)
CMIT/MIT induce apoptosis and inflammation in alveolar epithelial cells through p38/JNK/ERK1/2 signaling pathway
Lee J, et al.
Molecular & Cellular Toxicology, 15(1), 41-48 (2019)
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HPLC분석기기를 이용 중입니다. MIT/CMIT분석에 있어 표준용액으로 사용을 할 수 있나요?
1 respuesta-
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What is the diluent for PHR1597?
1 respuesta-
The solvent used for Product No. PHR1597 is water.
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