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Merck

PHR1045

Supelco

Diethylene glycol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

DEG, 2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol

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About This Item

Fórmula lineal:
(HOCH2CH2)2O
Número de CAS:
Peso molecular:
106.12
Beilstein:
969209
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to Ph. Eur. Y0000217
traceable to USP 1193265

densidad de vapor

2.14 (vs air)

presión de vapor

0.01 mmHg ( 20 °C)

familia API

diethylene glycol

CofA

current certificate can be downloaded

temp. de autoignición

442 °F

lim. expl.

2-12.3 %

técnicas

HPLC: suitable
gas chromatography (GC): suitable

índice de refracción

n20/D 1.447 (lit.)

bp

245 °C (lit.)

mp

−10 °C (lit.)

densidad

1.118 g/mL at 25 °C (lit.)

aplicaciones

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

Clave InChI

MTHSVFCYNBDYFN-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.

Aplicación

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Aplicación

Referencia del producto
Descripción
Precios

Producto relacionado

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

280.4 °F - closed cup

Punto de inflamabilidad (°C)

138 °C - closed cup


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
Bar.BD, et al.
Journal of Analytical Toxicology, 31(6), 295-303 (2007)
Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol
Ferrari.AL and Giannuzzi L
Forensic Science International, 153, 45-51 (2005)
Gas-chromatographic determination of ethylene glycol in serum
Porter H.W and Auansakul aA
Clinical Chemistry, 28, 75-78 (1982)
Tao Zhou et al.
Journal of separation science, 30(16), 2620-2627 (2007-09-21)
A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. The derivatization reagent p-toluenesulfonyl isocyanate (TSIC, 10 microL, 20% in ACN v/v) was
Ze-Jian Wang et al.
Journal of photochemistry and photobiology. B, Biology, 115, 16-24 (2012-07-17)
Photodynamic therapy (PDT) has recently been proposed as a possible indication in the conservative treatment of hereditary retinoblastoma. In order to create photosensitizers with enhanced targeting ability toward retinoblastoma cells, meso-tetraphenylporphyrins bearing one glycodendrimeric moiety have been synthesized. The binding

Chromatograms

suitable for GC

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