G5882

Glutaraldehyde solution

Grade I, 25% in H₂O, specially purified for use as an electron microscopy fixative

• Sinónimos: Glutaric dialdehyde solution, Pentane-1,5-dial
• Fórmula lineal: OHC(CH₂)₃CHO
• Número de CAS: 111-30-8
• Peso molecular: 100.12
• Beilstein: 605390
• Número MDL: MFCD00007025
• Código UNSPSC: 12352114
• ID de la sustancia en PubChem: 24895235
• NACRES: NA.21

Propiedades

• Nivel de calidad: 300
• tpo: Grade I
• formulario: liquid
• concentración: 25% in H₂O
• técnicas: electron microscopy: suitable (fixative); electron microscopy: suitable
• color: colorless
• intervalo de pH útil: 2.9
• mp: -10 °C ((14 °F ))
• solubilidad: water: soluble at 20 °C
• aplicaciones: cell analysis
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [H]C(CCCC([H])=O)=O
• InChI: 1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
• Clave InChI: SXRSQZLOMIGNAQ-UHFFFAOYSA-N

Descripción

Descripción general

Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde widely utilized as a versatile biochemical reagent. Glutaraldehyde solutions contain both monomers and polymers with the difference in their fixation properties. Its applications include serving as a protein crosslinker, facilitating enzyme immobilization in microscopy, histochemistry, and cytochemistry. This compound acts as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for diverse morphological studies.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.

Aplicación

Glutaraldehyde solution has been used:

• to fix the blood samples for scanning electron microscopy (SEM)
• to fix scaffold pieces for SEM analysis
• in drug treatments to treat K562 (leukemia) cells to permanently cross-link cell components

Acciones bioquímicas o fisiológicas

Glutaraldehyde can be used in biomedical research to fix cells. It can also be used as a tool to investigate healthy and pathologic red blood cells. Medical equipment like spirometry tubing, endoscopes, dialyzers, hemodialysis proportioning and dialysate delivery systems, endocavitary probes, transducers, anesthesia and respiratory therapy equipment, and reuse of laparoscopic disposable plastic trocars can be disinfected with glutaraldehyde.

Características y beneficios

• Versatile and adaptable for wide variety of research applications
• Ready-made solution reduces the need for preparation time

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Recommended for techniques demanding high purity.

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Información de seguridad

• Pictogramas: GHS08,GHS05,GHS07,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H302 + H332,H314,H317,H334,H335,H410
• Consejos de prudencia: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 8A - Combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter