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Merck

C4786

Supelco

Cefoxitin sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C16H16N3NaO7S2
Número de CAS:
Peso molecular:
449.43
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

formulario

powder or granules

Nivel de calidad

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

forensics and toxicology
pharmaceutical (small molecule)
veterinary

temp. de almacenamiento

2-8°C

cadena SMILES

[Na+].CO[C@]2(NC(=O)Cc1cccs1)C3SCC(COC(N)=O)=C(N3C2=O)C([O-])=O

InChI

1S/C16H17N3O7S2.Na/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19;/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22);/q;+1/p-1/t14-,16+;/m1./s1

Clave InChI

GNWUOVJNSFPWDD-XMZRARIVSA-M

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Descripción general

Cefoxitin is a β-lactam that belongs to the group of cephamycin antibiotics and is considered a 2nd generation cephalosporin. It shows resistance to β-lactamases and is used to treat a broad spectrum of bacterial infections caused by gram-positive and gram-negative bacteria, such as bronchitis, pharyngitis, meningitis, and urinary tract infection among others. It is used for intravenous and intramuscular injections. It is found to be active against Bacteroides and is therapeutically used for the treatment of mixed aerobic-anaerobic infections.

Aplicación

The analytical standard can be used to:
  • Determine cefoxitin sodium using four stability-indicating spectrophotometric methods in the presence of its alkaline degradation products in its pure form and pharmaceutical dosage forms
  • Separate and measure cefoxitin sodium in commercial drug products by high-performance liquid chromatography (HPLC)

Otras notas

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Skin Sens. 1B

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificados de análisis (COA)

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Spectrofluorimetric analysis of cefoxitin in pharmaceutical dosage
Talanta, 41(4), 557-563 (1994)
Methicillin-resistant Staphylococcus aureus screening by online immunometric monitoring of bacterial growth under selective pressure.
Stenholm T, et al.
Antimicrobial Agents and Chemotherapy, 53(12), 5088-5094 (2009)
Antibiotic and chemotherapy e-book, 14(3), 257-266 (2010)
Analysis of binary mixtures of cephalothin and cefoxitin by using first-derivative spectrophotometry
Murillo.A.J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 14(3), 257-266 (1996)
Raphaël Lepeule et al.
Antimicrobial agents and chemotherapy, 56(3), 1376-1381 (2012-01-05)
We investigated the efficiency of the cephamycin cefoxitin as an alternative to carbapenems for the treatment of urinary tract infections (UTIs) due to Escherichia coli producing CTX-M-type extended-spectrum β-lactamases. The susceptible, UTI-inducing E. coli CFT073-RR strain and its transconjugant CFT073-RR

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