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17849

Sigma-Aldrich

Enrofloxacin

≥99.0%

Sinónimos:

Baytril

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5 G
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About This Item

Fórmula empírica (notación de Hill):
C19H22FN3O3
Número de CAS:
93106-60-6
Peso molecular:
359.39
Beilstein:
5307824
Número MDL:
MFCD00792463
Código UNSPSC:
41116105
ID de la sustancia en PubChem:
329751571
NACRES:
NA.21

152,00 €

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Nivel de calidad

200

Ensayo

≥99.0%
99.0-101.0% (dried substance)

Formulario

powder or crystals

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

DNA synthesis | interferes
enzyme | inhibits

cadena SMILES

CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4

InChI

1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)

Clave InChI

SPFYMRJSYKOXGV-UHFFFAOYSA-N

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Descripción general

Chemical structure: fluoroquinolone
Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.[1][2][3]

Aplicación

Enrofloxacin has been used:
  • to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells[1]
  • to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)[2]
  • as an analyte in a chemiluminescence reagent system[4]

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Danger

Frases de peligro

H302,H317,H334

Clasificaciones de peligro

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000405073
0000395311
0000327714
0000317511
0000395311

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Yanina N Martínez et al.
Bioresource technology, 145, 280-284 (2013-04-06)
A keratinase isolated from Paecilomyces lilacinus (LPS #876) was tested against proteins present in the skin but the high enzyme activity was detected on collagen. Keratinase was physically immobilized onto PVA-pectin cryogels and enzyme release was 20.8±2.1%, 63.8±0.2%, 41.5±3.5% and
Jessica M Terry et al.
The Analyst, 136(5), 913-919 (2010-12-04)
Constructing flow-through reactors for chemiluminescence detection by machining channels into polymer disks has enabled the exploration of new configurations and materials that can improve signal intensity beyond that attainable with the traditional coiled-tubing design. Several approaches to merge reactant solutions
Geaneth Pertunia Mashile et al.
Polymers, 12(5) (2020-05-16)
The application of a magnetic mesoporous carbon/β-cyclodextrin-chitosan (MMPC/Cyc-Chit) nanocomposite for the adsorptive removal of danofloxacin (DANO), enrofloxacin (ENRO) and levofloxacin (LEVO) from aqueous and environmental samples is reported in this study. The morphology and surface characteristics of the magnetic nanocomposite
Sook Mei Khor et al.
Analytical and bioanalytical chemistry, 405(11), 3889-3898 (2013-02-27)
A displacement immunoassay involves having a labelled analogue of the analyte (the epitope) already bound to the antibody. The presence of the analyte causes a competition for antibodies, and some of the antibodies dissociates from the epitope so that it
Kristine H Wammer et al.
Water research, 47(1), 439-448 (2012-11-13)
Fluoroquinolone (FQ) antibacterial compounds are frequently detected in the aquatic environment, and photodegradation is expected to play an important role in FQ fate in some sunlit surface waters. This study investigated the direct aquatic photochemistry of three FQs: norfloxacin, ofloxacin
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