09668

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate

≥99.0% (TLC/N)

• Sinónimos: O-(N-Succinimidyl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, HSTU
• Fórmula empírica (notación de Hill): C₉H₁₆F₆N₃O₃P
• Número CAS: 265651-18-1
• Peso molecular: 359.21
• NACRES: NA.22
• PubChem Substance ID: 329748793
• UNSPSC Code: 12352101
• MDL number: MFCD01863753

Propiedades

• Quality Segment: 200
• assay: ≥99.0% (TLC/N)
• form: crystals
• reaction suitability: reaction type: Coupling Reactions
• mp: 218-221 °C (dec.)
• solubility: acetonitrile: 0.5 g/mL, slightly hazy, colorless
• application(s): peptide synthesis
• storage temp.: −20°C
• SMILES string: F[P-](F)(F)(F)(F)F.CN(C)C(\ON1C(=O)CCC1=O)=[N+](\C)C
• InChI: 1S/C9H16N3O3.F6P/c1-10(2)9(11(3)4)15-12-7(13)5-6-8(12)14;1-7(2,3,4,5)6/h5-6H2,1-4H3;/q+1;-1
• InChI key: STWZCCVNXFLDDD-UHFFFAOYSA-N

Descripción

General description

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate can be used to prepare N-succinimidyl 4-[¹⁸F]fluorobenzoate ([¹⁸F]-SFB), a prosthetic group for the fluorination of biomolecules for PET imaging.

Application

Reactant for:
Synthesis of liposomal contrast agents for magnetic resonance imaging
Synthesis of thiol-reactive Cy5 derivatives
Synthesis of protein labeling molecules

Other Notes

Coupling reagent for peptide synthesis and the formation of other amides. Even in aqueous solution yields are excellent

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves