During the catalytic reaction of copper amine oxidase, one of the two prochiral hydrogen atoms at the C1 position of substrate amine is stereoselectively abstracted by a conserved Asp residue serving as a general base. Using stereospecifically deuterium-labeled enantiomers of
Chemical research in toxicology, 22(8), 1447-1453 (2009-07-21)
Certain types of low molecular weight chemicals have the ability to cause respiratory sensitization via haptenation of carrier proteins. It has been suggested that such chemicals must contain multiple "reactive" functional groups to elicit an immune response. In contrast to
Dalton transactions (Cambridge, England : 2003), (43)(43), 9587-9594 (2009-10-28)
The new ligand L(6)(2)4E (N,N,N',N'-tetrakis(5-ethyl-2-pyridylmethyl)ethane-1,2-diamine) was designed as a more robust analog of TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine) for which the ability at stabilizing high valent Fe-Oxo and Fe-(hydro)peroxo has been reported. With respect to the latter, the pyridyl beta-substituents in L(6)(2)4E do
Journal of chromatography. A, 1216(15), 3280-3289 (2009-03-10)
Complementary methods using liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS) and comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOF-MS) were developed and applied to determine targeted metabolites involved in central carbon metabolism [including tricarboxylic acid cycle, serine cycle, ethylmalonyl-coenzyme A (ethylmalonyl-CoA) pathway
The journal of physical chemistry. A, 113(2), 399-410 (2008-12-23)
Neutral serotonin-(H(2)O)(n) clusters with n = 1,2 have been studied under jet-cooled conditions using a combination of resonant two-photon ionization (R2PI), UV-UV hole-burning (UVHB), and resonant ion-dip infrared (RIDIR) spectroscopy. Serotonin (5-hydroxytryptamine, SERO) is a close analogue of tryptamine, differing
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