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Documentos

02000585

Silybin

mixture of Silybin A and B, primary reference standard

Sinónimos:

(2R,3R)-3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]chroman-4-one, Silibinin

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About This Item

Fórmula empírica (notación de Hill):
C25H22O10
Número de CAS:
802918-57-6
Peso molecular:
482.44
Número CE:
245-302-5
Código UNSPSC:
85151701
NACRES:
NA.24

grado

primary reference standard

calidad

mixture of Silybin A and B

caducidad

limited shelf life, expiry date on the label

fabricante / nombre comercial

HWI

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

food and beverages

cadena SMILES

COc1cc(ccc1O)C2Oc3cc(ccc3OC2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1

Clave InChI

SEBFKMXJBCUCAI-DBMPWETRSA-N

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Descripción general

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Aplicación

Reference standard in the analysis of herbal medicinal products.

Otras notas

This compound is commonly found in plants of the genus: silybum

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Choose from one of the most recent versions:

Certificados de análisis (COA)

Lot/Batch Number
HWI03227
HWI019512
HWI01951-2
HWI01951-1
HWI01951

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Sigma-Aldrich

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Yi-Xin Wang et al.
Asian Pacific journal of cancer prevention : APJCP, 15(16), 6791-6798 (2014-08-30)
To investigate the effect of silibinin on proliferation and apoptosis in human gastric cancer cell line MGC803 and its possible mechanisms. Human gastric cancer cell line MGC803 cells were treated with various concentration of silibinin. Cellular viability was assessed by
Suvadra Das et al.
PloS one, 9(7), e101818-e101818 (2014-07-06)
Silybin, is one imminent therapeutic for drug induced hepatotoxicity, human prostate adenocarcinoma and other degenerative organ diseases. Recent evidences suggest that silybin influences gluconeogenesis pathways favorably and is beneficial in the treatment of type 1 and type 2 diabetes. The
Peng Liu et al.
In vitro cellular & developmental biology. Animal, 50(10), 899-908 (2014-08-26)
To investigate the effects of icaritin, an active ingredient extracted from Epimedium Sagittatum (Sieb. et Zucc.), on CCl4-induced liver injury and its possible mechanisms. Hepatocytes isolated from Sprague-Dawley male rats were treated with 3 mmol/L CCl4 for 24 h to
Hong-Li Zhang et al.
Biological & pharmaceutical bulletin, 37(7), 1214-1220 (2014-04-25)
Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-hepatitis B virus (HBV) and anti-human immunodeficiency
Weiquan Zhao et al.
Journal of separation science, 37(17), 2300-2306 (2014-06-14)
Silymarin extracted from Silybum marianum (L.) Gaertn consists of a large number of flavonolignans, of which diastereoisomeric flavonolignans including silybin A and silybin B, and isosilybin A and isosilybin B are the main bioactive components, whose preparation from the crude
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