MABN350

Anti-NTR1 Antibody, clone 8F11.1

clone 8F11.1, from mouse

• Sinónimos: Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 8F11.1, monoclonal
• reactividad de especies: human, mouse
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_002522
• Nº de acceso UniProt: P30989
• Condiciones de envío: dry ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TFIP11(24144)

Descripción

Descripción general

Neurotensin receptor type 1 (UniProt P30989; also known as High-affinity levocabastine-insensitive neurotensin receptor, NT-R-1, NTR1, NTRH) is encoded by the NTSR1 (also known as NTRR) gene (Gene ID 4923) in human. Neurotensin (NT) is a tridecapeptide that acts as a neuromodulator in the CNS. It also behaves as a hormone in the gastrointestinal tract. Four different NTSRs have been reported. NTSR1 and NTSR2 are seven-transmembrane G-protein-coupled receptors (GPCRs), while NTSR3 and NTSR4 are members of the sortilin protein family with a single-transmembrane spanning domain. NTSR1 is a high affinity NT receptor and plays an important role in cancer cell proliferation, survival, mobility, and invasion. NT has also been implicated in the pathophysiology of several CNS disorders, such as schizophrenia, drug abuse, eating disorders, and Parkinson’s disease.

Inmunógeno

Epitope: Near C-terminus

KLH-conjugated linear peptide corresponding to human NTR1 near the C-terminus.

Aplicación

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected NTR1 in human thalamus and human frontal cortex tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-NTR1 Antibody, clone 8F11.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of NTR1 .

Calidad

Evaluated by Western Blotting in mouse hypothalamus tissue lysate.

Western Blotting Analysis: 2.5 µg/mL of this antibody detected NTR1 in 10 µg of mouse hypothalamus tissue lysate.

Descripción de destino

~49 kDa observed. Uncharacterized band(s) may appear in some lysates.

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable