Saltar al contenido
Merck
Todas las fotos(2)

Documentos clave

MABN2613

Sigma-Aldrich

Anti-RTN/NOGO-A Antibody, clone NG1

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Seleccione un Tamaño

25 μG
154,00 €
100 μG
389,00 €

154,00 €


Fecha estimada de envío12 de marzo de 2025Detalles


Solicitar un pedido a granel

Seleccione un Tamaño

Cambiar Vistas
25 μG
154,00 €
100 μG
389,00 €

About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

154,00 €


Fecha estimada de envío12 de marzo de 2025Detalles


Solicitar un pedido a granel

origen biológico

hamster

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

purified antibody

tipo de anticuerpo

primary antibodies

clon

NG1, monoclonal

mol peso

calculated mol wt 126.61 kDa

purificado por

using protein G

reactividad de especies

mouse

envase

antibody small pack of 100 μg

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

isotipo

IgG

secuencia del epítopo

Unknown

Nº de acceso Protein ID

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

2-8°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

mouse ... Rtn4(68585)

Descripción general

Reticulon-4 (UniProt: Q99P72; also known as Neurite outgrowth inhibitor, Nogo protein) is encoded by the Rtn4 (also known as Kiaa0886, Nogo) gene (Gene ID: 68585) in murine species. NOGO proteins are required for the formation and stabilization of endoplasmic reticulum (ER) tubules. They are also involved in nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. Three isoforms of NOGO have been described that share a common C-terminal domain but differ in their N-terminal sequence. NOGO-A is the longest isoform and is considered as a developmental neurite growth factor. It acts as a negative regulator of axon-axon adhesion and growth, but also acts as a facilitator of neurite branching. In the adult central nervous system (CNS), it is involved in down-regulation of growth, stabilization of wiring, and restriction of plasticity. It can also serve as a negative regulator of CNS angiogenesis by blocking spreading, migration, and sprouting of primary brain microvascular endothelial cells. Isoform B mainly functions in the endothelial cells and vascular smooth muscle cells. It promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Isoform C regulates cardiomyocyte apoptosis under hypoxic conditions. Clone NG1 recognizes NOGA-A but does not react with other isoforms. It is shown to strongly bind olfactory bulb axons in the lateral olfactory tract as well as some other growing axons in nervous system. This clone has been use to show that knockdown of NOGO-A reduces the number of axonal collateral branches in olfactory bulb. (Ref.: Iketani, M., et al. (2016). Sci. Rep. 6; 39586; Petrinovic, MM., et al. (2010). Development. 137(15); 2539-2550; Tozaki, H., et al. (2002). Mol. Brain Res. 104(2); 111-119).

Especificidad

Clone NG1 is an Armenian Hamster monoclonal antibody that detects murine Reticulon-4 (RTN4).

Inmunógeno

Lateral olfactory tract of E14.5 mouse embryos fixed with 4% paraformaldehyde in phosphate-buffered saline (PBS), washed and suspended in PBS.

Aplicación

Quality Control Testing

Evaluated by Immunohistochemistry in E14 mouse embryo frozen tissue sections.

Immunohistochemistry Applications: A 1:200 dilution of this antibody detected RTN/NOGO-A in E14 mouse embryo frozen tissue sections.

Tested Applications

Immunohistochemistry Application: A representative lot detected RTN/NOGO-A in Immunohistochemistry applications (Iketani, M., et al. (2016). Sci Rep. 6:39586; Tozaki, H., et al. (2002). Brain Res Mol Brain Res. 104(2):111-9).

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-RTN/NOGO-A, clone NG1, Cat. No. MABN2613, is an Armenian hamster monoclonal antibody that detects Reticulon-4 and is tested for use in Immunohistochemistry.

Forma física

Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Recommend storage at +2°C to +8°C. For long term storage antibodies can be kept at -20°C. Avoid repeated freeze-thaws.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Preguntas

Revisiones

Sin puntuación

Filtros activos

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico