MABE78
Anti-MiTF Antibody, clone 3D1.2
clone 3D1.2, from mouse
Sinónimos:
Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
3D1.2, monoclonal
reactividad de especies
human, mouse
técnicas
immunohistochemistry: suitable
western blot: suitable
isotipo
IgMκ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... MITF(4286)
Descripción general
Microphthalmia-associated transcription factor (MiTF) is a basic helix loop helix leucine zipper (b HLH ZIP) transcription factor implicated in pigmentation, and development of mast cells and bone. Mutations in MiTF cause auditory pigmentary syndromes in humans, such as Waardenburg syndrome type II and type IIa, and Tietz syndrome. There are two known isoforms of MiTF, differing by 66 amino acids at the N-terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, whereas the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart. MiTF plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Inmunógeno
GST-tagged recombinant protein corresponding to human MiTF.
Aplicación
Anti-MiTF Antibody, clone 3D1.2 is an antibody against MiTF for use in Western Blotting & IHC.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MiTF in human melanoma tissue.
Research Category
Signaling
Signaling
Research Sub Category
Transcription Factors
Transcription Factors
Calidad
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected MiTF in 10 µg of mouse brain tissue lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected MiTF in 10 µg of mouse brain tissue lysate.
Descripción de destino
~52 kDa observed. Multiple isoforms between 46-56 kDa are known to exist.
Ligadura / enlace
Replaces: MAB3747
Forma física
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing 0.01M PBS, 0.1% sodium azide, pH 7.1.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt.
Nota de análisis
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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