The HC5B-140K single plex has been tested with HCMPEX1-19K and HCMP2MAG-19K. Cross reactivity is observed with C5, C5a, and C9 in HCMPEX1-19K. However, no cross reactivity is observed with any analytes in HCMP2MAG-19K. There hasn't been testing for cross reactivity between HCMPEX1-19K and HCMP2MAG-19K.
HCMPEX1-19K
MILLIPLEX® Human Complement Expanded Panel 1
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About This Item
Código UNSPSC:
12161503
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
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fabricante / nombre comercial
Milliplex®
Nivel de calidad
técnicas
multiplexing: suitable
método de detección
fluorometric
Condiciones de envío
wet ice
temp. de almacenamiento
2-8°C
Descripción general
The complement system consists of a large number of plasma proteins that assist, or complement, the ability of phagocytic cells and antibodies to clear pathogens. Although it is part of the innate immune system, not adaptable and unchanging over the course of a lifetime, it can be recruited and activated by the adaptive immune system. The system proteins and glycoproteins that are synthesized primarily by hepatocytes normally circulate as inactive pro-proteins. Once stimulated the end result of the cascade is a massive amplification of response and activation of the membrane attack complex, which forms a transmembrane pore causing osmotic lysis of target cells.
The complement system consists of three different simultaneous pathways. The classical pathway is stimulated by antigen-antibody complexes; the alternative pathway spontaneously activates on contact with pathogenic cell surfaces; the mannose-binding lectin pathway recognizes mannose sugars usually present only on pathogenic cell surfaces.
The complement system is thought to play a key role in many diseases with an immune component, such as asthma or sepsis, and in many autoimmune diseases, including systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis. It is also becoming increasingly associated with neurological diseases, such as Alzheimer’s Disease, and conditions such as spinal cord injuries. The MILLIPLEX® Human Complement Expanded Panel 1 is a 9-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma, or culture supernatant samples: C2, C4b, C5, C5a, C9, Factor D (Adipsin), Factor I, Mannose-Binding Lectin (MBL), and Properdin.
The complement system consists of three different simultaneous pathways. The classical pathway is stimulated by antigen-antibody complexes; the alternative pathway spontaneously activates on contact with pathogenic cell surfaces; the mannose-binding lectin pathway recognizes mannose sugars usually present only on pathogenic cell surfaces.
The complement system is thought to play a key role in many diseases with an immune component, such as asthma or sepsis, and in many autoimmune diseases, including systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis. It is also becoming increasingly associated with neurological diseases, such as Alzheimer’s Disease, and conditions such as spinal cord injuries. The MILLIPLEX® Human Complement Expanded Panel 1 is a 9-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma, or culture supernatant samples: C2, C4b, C5, C5a, C9, Factor D (Adipsin), Factor I, Mannose-Binding Lectin (MBL), and Properdin.
Envase
96-well plate
Información legal
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
Órganos de actuación
Respiratory Tract
Código de clase de almacenamiento
10 - Combustible liquids
Certificados de análisis (COA)
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Contenido relacionado
Immunology multiplex assays, like MILLIPLEX® assays, allow researchers to investigate more immune biomarkers simultaneously, saving time and resources. This is especially critical to immunology research, where numerous analytes play a role in different pathways.
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Is there any available data on mixing and matching the complement markers across the three panels? Additionally, is there any data on spiking the C5b-9 analyte into the other two panels?
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