ABN1038
Anti-Fbxo7 Antibody
Sinónimos:
F-box only protein 7|Fbxo7
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
clon
polyclonal
reactividad de especies
mouse, human
técnicas
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Descripción general
F-box only protein 7 (UniProt Q9Y3I1) is encoded by the FBXO7 (Also known as FBX, FBX7, PKPS, FBX07, PARK15) gene in human (Gene ID 25793). The Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligase complexes rely on their F-box protein component for substrate recognition. In addition to Fbxs, to which Fbxo7 belongs, there exist two other classes of F-box proteins, Fbws and Fbls. Fbxo7 recruits substrate via its C-terminal proline rich domain and associates with the adapter protein Skp1 via its F-box domain. In addition to mediating SCF-dependent ubiquitination, Fbxo7 is also involved in SCF-independent activities. Fbxo7 is reported to participate in autophagic clearance of damaged mitochondria (mitophagy) in response to mitochondrial depolarisation through direct interaction with PINK1 (PARK6) and Parkin (PARK2), while Parkinson′s disease-associated Fbxo7 mutations affect Parkin mitochondrial translocation and Parkin-mediated mitophagy.
Inmunógeno
KLH-conjugated linear peptide corresponding to the C-terminus of human Fbxo7.
Aplicación
Anti-Fbxo7 Antibody is an antibody against Fbxo7 for use in Western Blotting, Immunohistochemistry, Immunocytochemistry.
Immunohistochemistry Analysis: A 1:400 dilution from a representative lot detected Fbxo7 in human tonsil tissue.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Fbxo7 using U2OS cells transfected with constructs expres
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Fbxo7 using U2OS cells transfected with constructs expres
Calidad
Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 1.0 ug/mL of this antibody detected Fbxo7 in 10 ug of Jurkat cell lysate.
Western Blotting Analysis: 1.0 ug/mL of this antibody detected Fbxo7 in 10 ug of Jurkat cell lysate.
Otras notas
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico