8.51008

TBTU

≥98.0% (HPLC), for peptide synthesis, Novabiochem^®

• Sinónimos: TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate
• Fórmula empírica (notación de Hill): C₁₁H₁₆BF₄N₅O
• Número de CAS: 125700-67-6
• Peso molecular: 321.08
• Número MDL: MFCD00077413
• Código UNSPSC: 12352107
• Número índice de la CE: 423-040-4
• NACRES: NA.22

Propiedades

• product name: TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem^®
• Nivel de calidad: 200
• Línea del producto: Novabiochem^®
• Análisis: ≥98.0% (HPLC)
• formulario: powder
• idoneidad de la reacción: reaction type: Coupling Reactions
• fabricante / nombre comercial: Novabiochem^®
• mp: 195-199 °C (decomposes)
• aplicaciones: peptide synthesis
• temp. de almacenamiento: 15-25°C
• InChI: 1S/C11H16N5O.B.4FH/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;;;;;/h5-8H,1-4H3;;4*1H/q+1;+3;;;;/p-4
• Clave InChI: SHGLJDNRZIDILW-UHFFFAOYSA-J

Descripción

Descripción general

See entry for HBTU (851006). TBTU has been employed to generate 1,2,4-oxadiazoles from carboxylic acids ^[1].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.

Aplicación

• Synthesis of phospho-urodilatin by combination of global phosphorylation with the segment coupling approach.: This research focuses on the synthesis of phospho-urodilatin, demonstrating the effectiveness of TBTU as a coupling reagent in segment coupling strategies for peptide synthesis (Mostafavi et al., 1996).


• Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.: The study investigates the impact of tertiary amines on carbodiimide-mediated peptide synthesis, highlighting the role of TBTU in enhancing peptide coupling efficiency (Beyermann et al., 1991).

Ligadura / enlace

Replaces: 01-62-0015

Nota de análisis

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %

Información legal

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H228 - H317
• Consejos de prudencia: P210 - P240 - P241 - P261 - P280 - P302 + P352
• Clasificaciones de peligro: Flam. Sol. 1 - Skin Sens. 1A
• Código de clase de almacenamiento: 4.1A - Other explosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable