8.17073

Fumaric acid

EMPROVE^® ESSENTIAL, NF, JPE

• Sinónimos: Fumaric acid, trans-1,2-Ethylentricarboxylic acid
• Fórmula empírica (notación de Hill): C₄H₄O₄
• Número de CAS: 110-17-8
• Peso molecular: 116.07
• Número MDL: MFCD00002700
• Código UNSPSC: 12352106
• Número índice de la CE: 203-743-0

Propiedades

• Agency: JPE; NF
• Nivel de calidad: 500
• presión de vapor: <0.001 hPa ( 20 °C)
• Línea del producto: EMPROVE^® ESSENTIAL
• formulario: solid
• temp. de autoignición: 375 °C
• potencia: 9300 mg/kg LD₅₀, oral (Rat); 20000 mg/kg LD₅₀, skin (Rabbit)
• técnicas: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 2.1 (20 °C, 4.9 g/L in H₂O)
• bp: 290 °C/1013 hPa (sublimed)
• mp: 287 °C
• temperatura de transición: flash point 273 °C
• solubilidad: 4.9 g/L
• densidad: 1.64 g/cm³ at 20 °C
• aplicaciones: liquid formulation; pharmaceutical; solid formulation
• temp. de almacenamiento: 15-25°C
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
• Clave InChI: VZCYOOQTPOCHFL-OWOJBTEDSA-N

Descripción

Descripción general

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Fumaric acid is a commonly used ingredient in both food and pharmaceutical applications. In pharmaceutical applications, fumaric acid has been used primarily as a pH modifier.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 523.4 °F
• Punto de inflamabilidad (°C): 273 °C