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677181

Vincristine Sulfate

Name: Vincristine Sulfate
Brand: MM
Price: 459 EUR

≥98% (TLC), Microtuble disruptor, solid

Sinónimos:

Vincristine Sulfate, Apocynaceae sp.

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A ustedes/SKU	Disponibilidad	Precio
10 mg	Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	459,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₄₆H₅₆N₄O₁₀ · xH₂SO₄

Número CAS:

2068-78-2

Peso molecular:

824.96 (free base basis)

UNSPSC Code:

12352210

NACRES:

NA.77

MDL number:

MFCD00084729

Assay:

≥98% (TLC)

Form:

solid

Storage condition:

OK to freeze

459,00 €

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Propiedades

Nombre del producto

Vincristine Sulfate, Apocynaceae sp., Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

Quality Segment

100

description

Merck USA index - 14, 9986

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)([O-])[O-].[N+H]21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@@H]5[C@]64[C@H]7[N+H](CC6)CC=C[C@]7([C@H]([C@]5(O)C(=O)OC)OC(=O)C)CC)C=O)C(=O)OC

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

InChI key

AQTQHPDCURKLKT-JKDPCDLQSA-N

Descripción

General description

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Other Notes

Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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Este artículo	376650	499610	569396
Sigma-Aldrich 677181 Vincristine Sulfate, Apocynaceae sp.	Sigma-Aldrich 376650 D-erythro-Sphingosine, N-Hexanoyl-	Sigma-Aldrich 499610 (5Z)-7-Oxozeaenol, Curvularia sp.	Sigma-Aldrich 569396 Staurosporine, Streptomyces sp.
description Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.	description Biologically active, cell-permeable, non-physiological ceramide analog.	description (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).	description InSolution, ≥97%, 1 mM solution, protein kinase inhibitor
form solid	form waxy solid	form solid	form liquid
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −70°C
solubility water: 20 mg/mL	solubility ethanol: 25 mg/mL, DMSO: soluble	solubility DMSO: 10 mg/mL, ethanol: 5 mg/mL	solubility -

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H341,H361fd

pcodes

P202 - P264 - P270 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 2 Oral - Muta. 2 - Repr. 2

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c