585970

(±)-Thalidomide

Selective inhibitor of TNF-α biosynthesis.

• Sinónimos: (±)-Thalidomide, (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Fórmula empírica (notación de Hill): C₁₃H₁₀N₂O₄
• Número de CAS: 50-35-1
• Peso molecular: 258.23
• Número MDL: MFCD00153873
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: DMSO: 25 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• Clave InChI: UEJJHQNACJXSKW-UHFFFAOYSA-N

Descripción

Descripción general

Selective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Selective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
TNF-α biosynthesis

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitución

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Gershon, D. 1995. Nat. Med.1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H312,H360D
• Consejos de prudencia: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Clasificaciones de peligro: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3