580551

Tautomycin, Streptomyces spiroverticillatus

Tautomycin, CAS 109946-35-2, is a potent inhibitor of protein phosphatase 1, 2A, and smooth muscle endogenous phosphatase (IC₅₀ = 1 nM, 10 nM, and 6 nM, respectively). Mixture of two isomers.

• Sinónimos: Tautomycin, Streptomyces spiroverticillatus
• Fórmula empírica (notación de Hill): C₄₁H₆₆O₁₃
• Número de CAS: 109946-35-2
• Peso molecular: 766.95
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥97% (HPLC)
• formulario: lyophilized (thin film)
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated; protect from light
• solubilidad: chloroform: soluble; ethanol: soluble; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1
• Clave InChI: RFCWHQNNCOJYTR-IRCAEPKSSA-N

Descripción

Descripción general

Mixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.

Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
PP1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively

Advertencia

Toxicity: Highly Toxic (H)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"

- removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase"

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

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Kikuchi, K., et al. 1999. Int. J. Mol. Med.4, 395.
Sheppeck, J.E., et al. 1997. J. Org. Chem.62, 387.
Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett.6, 3.
Gong, M.C., et al. 1992. J. Biol. Chem.267, 14662.
Suganuma, M., et al. 1992. Toxicon30, 873.
MacKintosh, C. and Klumpp, S. 1990. FEBS Lett.277, 137.
Magae, J., et al. 1989. J. Antibiot.42, 1290.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable