559393-M

SB 202190, Hydrochloride

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

• Sinónimos: SB 202190, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
• Fórmula empírica (notación de Hill): C₂₀H₁₄FN₃O · xHCl
• Número de CAS: 350228-36-3
• Peso molecular: 331.34 (free base basis)
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥97% (HPLC)
• formulario: solid
• potencia: 16 nM K_i
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: amber
• solubilidad: water: 0.5 mg/mL (slightly soluble); DMSO: soluble
• temp. de almacenamiento: −20°C
• InChI: 1S/C20H14FN3O.ClH/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;/h1-12,25H,(H,23,24);1H
• Clave InChI: XOQSUTIMRLPFPB-UHFFFAOYSA-N

Descripción

Descripción general

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

Acciones bioquímicas o fisiológicas

Target IC₅₀: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable