559292

RSK Inhibitor, SL0101

InSolution, ≥95%

• Sinónimos: InSolution RSK Inhibitor, SL0101
• Fórmula empírica (notación de Hill): C₂₅H₂₄O₁₂
• Peso molecular: 516.45
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC₅₀ = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (K_i = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. The solid form (Cat. No. 559285) is also available.

A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC₅₀ = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (K_i = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM.

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Forma física

A 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO.

Reconstitución

Following initial thaw, aliquot and freeze (-20°C).

Otras notas

Smith, J.A., et al. 2007. Bioorg. Med. Chem.15, 5018.
Smith, J.A., et al. 2006. Bioorg. Med. Chem.14, 6043.
Xu, Y.M., et al. 2006. Bioorg. Med. Chem.14, 3974.
Maloney, D.J. and Hecht, S.M., 2005. Org. Lett.7, 1097.
Smith, J.A., et al. 2005. Cancer Res.65, 1027.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Punto de inflamabilidad (°C): 87 °C - closed cup - (Dimethylsulfoxide)