553211
Rapamycin
≥95% (HPLC), solution, mTOR inhibitor, Calbiochem
Sinónimos:
InSolution Rapamycin, mTOR Inhibitor I
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Seleccione un Tamaño
500 μG
235,00 €
1 MG
353,00 €
Seleccione un Tamaño
Cambiar Vistas
500 μG
235,00 €
1 MG
353,00 €
About This Item
Fórmula empírica (notación de Hill):
C51H79NO13
Peso molecular:
914.17
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nombre del producto
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
Nivel de calidad
Ensayo
≥95% (HPLC)
Formulario
solution
fabricante / nombre comercial
Calbiochem®
condiciones de almacenamiento
desiccated (hygroscopic)
protect from light
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Descripción general
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Acciones bioquímicas o fisiológicas
Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
Envase
Packaged under inert gas
Advertencia
Toxicity: Irritant (B)
Forma física
2.5 mg/mL solution in DMSO (2.74 mM)
Reconstitución
Following initial use, aliquot and freeze (-20°C).
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto de inflamabilidad (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Rachel M Wise et al.
Cells, 9(10) (2020-10-04)
Human adipose-derived stem cells (ASCs) show immense promise for treating inflammatory diseases, attributed primarily to their potent paracrine signaling. Previous investigations demonstrated that short-term Rapamycin preconditioning of bone marrow-derived stem cells (BMSCs) elevated secretion of prostaglandin E2, a pleiotropic molecule
Tara Alpert et al.
Cell reports, 33(4), 108324-108324 (2020-10-29)
Nascent RNA sequencing has revealed that pre-mRNA splicing can occur shortly after introns emerge from RNA polymerase II (RNA Pol II). Differences in co-transcriptional splicing profiles suggest regulation by cis- and/or trans-acting factors. Here, we use single-molecule intron tracking (SMIT)
Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis.
Esmaeilian, et al.
Cell Death & Disease, 14, 342-342 (2023)
Clarissa Braun et al.
Cell stress, 5(12), 176-182 (2021-12-18)
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory processes. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). However, additional pathways that
Rachel M Wise et al.
Cells, 11(9) (2022-05-15)
Human adipose-derived stem cells (hASCs) are potent modulators of inflammation and promising candidates for the treatment of inflammatory and autoimmune diseases. Strategies to improve hASC survival and immunoregulation are active areas of investigation. Autophagy, a homeostatic and stress-induced degradative pathway
Filtros activos
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
