5.34356

PRMT5 Inhibitor, CMP5

• Sinónimos: PRMT5 Inhibitor, CMP5, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine, 2HCl, 1-(9-Ethyl-9H-carbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine, 2HCl
• Fórmula empírica (notación de Hill): C₂₁H₂₁N₃ · 2HCl
• Peso molecular: 388.33
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• Nivel de calidad: 100
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: yellow
• solubilidad: DMSO: 25 mg/mL; water: 50 mg/mL
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable carbazole based compound that selectively inhibits PRMT5 and not PRMT1, PRMT4 & PRMT7 activity. Shown to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. Prevents Epstein-Barr virus (EBV)-driven B cell immortalization and restores miR-96 transcriptional activity. Dose-dependently induces lymphoma cell death over normal resting B lymphocytes.

A cell-permeable carbazole based compound that selectively inhibits PRMT5 and not PRMT1, PRMT4 & PRMT7 activity. Shown to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 µM. Prevents Epstein-Barr virus (EBV)-driven B cell immortalization and restores miR-96 transcriptional activity. Dose-dependently induces lymphoma cell death over normal resting B lymphocytes.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
PRMT5

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Forma física

Supplied as HCl salt.

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Alinari, L., et al. 2015. Blood.125, 2530.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable