454861

MNK1 Inhibitor

The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: MNK1 Inhibitor, 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I
• Fórmula empírica (notación de Hill): C₁₁H₉FN₆
• Número de CAS: 522629-08-9
• Peso molecular: 244.23
• Número MDL: MFCD03861062
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: off-white
• solubilidad: DMSO: 15 mg/mL; ethanol: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
• Clave InChI: UQPMANVRZYYQMD-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC₅₀ = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC₅₀ = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Mitogen-activated protein kinase-interacting kinase 1 (MNK1)

Product competes with ATP.

Reversible: yes

Target IC₅₀: 2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells

Envase

Packaged under inert gas

Advertencia

Toxicity: Toxic (F)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Topisirovic, I., et al. 2004. Cancer Res.64, 8639.
Worch, J., et al. 2004. Oncogene23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev.18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem.277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol.21, 5500.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3