T-909

α-Hydroxytriazolam-d₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₇D₄H₈Cl₂N₄O
• Número de CAS: 145225-01-0
• Peso molecular: 363.23
• Número CE: 200-659-6
• Número MDL: MFCD00673313
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329826898
• NACRES: NA.24

Propiedades

• grado: certified reference material
• formulario: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• envase: ampule of 1 mL
• fabricante / nombre comercial: Cerilliant^®
• concentración: 100 μg/mL in methanol
• técnicas: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicaciones: clinical testing
• formato: single component solution
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OCC1=NN=C2N1C3=CC=C(Cl)C=C3C(C4=C([2H])C([2H])=C([2H])C([2H])=C4Cl)=NC2
• InChI: 1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2/i1D,2D,3D,4D
• Clave InChI: BHUYWUDMVCLHND-RHQRLBAQSA-N

Descripción

Descripción general

a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This stable-labeled internal standard is suitable for triazolam testing or isotope dilution methods by GC/MS or LC/MS for clinical toxicology, urine drug testing, pain prescription monitoring or forensic analysis.

Aplicación

• Pharmacokinetic Analysis of α-Hydroxytriazolam: A study focused on the urinary excretion of α-Hydroxytriazolam following a single dose of Halcion. This research provides critical insights into the metabolism of benzodiazepines, emphasizing the role of α-Hydroxytriazolam-d₄ as a stable isotope-labeled standard in tracing metabolic pathways in clinical pharmacology (Lin et al., 2005).


• Forensic Toxicology and Metabolite Confirmation: Another significant study utilized GC-MS to confirm the presence of urinary benzodiazepine metabolites, including α-Hydroxytriazolam. This research underscores the utility of α-Hydroxytriazolam-d₄ in forensic analysis, aiding in the detection and confirmation of benzodiazepine use and abuse in legal and medical settings (Meatherall, 1994).

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H225,H301 + H311 + H331,H370
• Consejos de prudencia: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órganos de actuación: Eyes
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 49.5 °F - closed cup
• Punto de inflamabilidad (°C): 9.7 °C - closed cup