454575

N-Methyl-D-aspartic Acid hydrate

>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem^®

• Sinónimos: N-Methyl-D-aspartic Acid, Hydrate, NMDA
• Fórmula empírica (notación de Hill): C₅H₉NO₄ · xH₂O
• Número de CAS: 6384-92-5
• Peso molecular: 147.13 (anhydrous basis)
• Número MDL: MFCD00004226
• Código UNSPSC: 12352209
• NACRES: NA.77

Propiedades

• product name: N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
• Nivel de calidad: 100
• Análisis: >95% (TLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white
• solubilidad: water: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
• Clave InChI: HOKKHZGPKSLGJE-GSVOUGTGSA-M

Descripción

Descripción general

An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
Glutamate receptor that regulates Ca2+ channels

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.

Otras notas

Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable